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KMID : 0385219940040010032
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Korean Journal of Gerontology
1994 Volume.4 No. 1 p.32 ~ p.38
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Study on Anti-aging Action of Docosahexaenoic Acid(DHA) in Rats 1. Effect of Docosahexaenoic Acid(DHA)-Rich Fish Oil on body Weight, Lipid Component and Fatty Acid Compositions in Rats
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Choi Jin-Ho
Kim Jae-Il
Kim Dong-Woo
Moon Young-Sil
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Abstract
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Recently, fish oil consumption has been linked to reduced rates of cardiovascular disease in Greenland Eskimos. Therefore, we were interested in the possible effects of fish oils on several risk factors for these diseases. Sprague Dawley rats were fed diets in different P/S ratios(0.4, 0.8, 1.2, 1.6)controlled of docosahexaenoic acid (DHA)-rich fish oil (EPA 6.63%, DHA 31.95%) for 10 weeks in order to investigate the effect of docosahexaenoic acid on body weight, triglyceride and cholesterol levels, and fatty acid composition in serum of rats. Body weights gain were slightly inhibited with the increase of DHA-rich oserved between liver weight and high DHA-rich fish oil of P/S ration 1.6(p<0.001). Triglycerides in serum almost did not change by the administration of DHA-rich fish oil, but total cholesterol in serum were remarkably fell in all DHA-rich fish oil groups(p<0.001). Cholesterol in liver membranes showed a similar trend to their cholesterol in serum, but cholesterol were consistently higher in microsome than in mitochondria. Eicosapentaenioc acid(EPA)and docosahexaenoic acid (DHA) in serum significantly increased with the administration of DHA-rich fish oil(p<0.001) but arachidonic acids almost did not change. EPA/AA and DHA/AA ratios in serum also significantly increased by 2.4 to 3.4, and 2.0 to 3.1 times in all DHA-rich fish oil groups compared with control group of P/S 0.4(p<0.001). These results suggest that docosahexaenioc acid may be due to intervention of lipid compositions with less total and LDL cholesterols and a larger EPA/AA and DHA/AA ratios in serum and liver membranes, resulting in a greater reduction of cardiovascular diseases and retardation of aging process.
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KEYWORD
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docosahexaenoic acid(DHA), DHA-rich fish oil, triglyceride(TG), LDL and HDL cholesterol, eicosapentaenoic acid(EPA)
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